A new method to determine dispersive surface energy site distributions by inverse gas chromatography
- Submitting institution
-
Imperial College of Science, Technology and Medicine
- Unit of assessment
- 12 - Engineering
- Output identifier
- 267
- Type
- D - Journal article
- DOI
-
10.1021/la500688d
- Title of journal
- Langmuir: the ACS journal of surfaces and colloids
- Article number
- -
- First page
- 8029
- Volume
- 30
- Issue
- 27
- ISSN
- 0743-7463
- Open access status
- Out of scope for open access requirements
- Month of publication
- June
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
10.1021/la500688d
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
3
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This method enables the deconvolution of surface energy profiles to site-specific distributions, providing an accurate description of powder anisotropy that had remained difficult to determine. Such descriptions are useful to predict powder manufacturability and formulation. This work has led to an EPSRC Future Manufacturing Systems (EP/N025261/1, £495k, 2020), EPSRC Future Formulation (EP/N025261/1, £1.75M, 2017), EPSRC CASE (Pfizer, 2013 and AstraZeneca, 2016) and a fully-funded PhD (AbbVie, 2016). This methodology has been employed on commercially relevant molecules in consultancy projects (Pfizer, 2015 and Genentech, 2018) and Heng served on the Scientific Advisory Board (major pharmaceutical company, 2015).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -