Electrochemical fecal pellet sensor for simultaneous real-time ex vivo detection of colonic serotonin signalling and motility
- Submitting institution
-
University of Brighton
- Unit of assessment
- 12 - Engineering
- Output identifier
- 7130380
- Type
- D - Journal article
- DOI
-
10.1038/srep23442
- Title of journal
- Scientific Reports
- Article number
- 23442
- First page
- -
- Volume
- 6
- Issue
- -
- ISSN
- 2045-2322
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
4
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Understanding the relationship between signalling and colonic motility is critical to understand diseased bowel function. This paper is significant as it developed and validated the first ever sensor device that can directly interface within the bowel. This sensing device represents a step-change compared to existing measurement approaches by providing physiological stimulus coupled with simultaneous real-time monitoring of bowel signalling and motility. This research underpinned two EPSRC grants (EP/N027345/1; EP/V028391/1) to develop a drug-eluting in vivo probe. This device is being adopted as a key technology by the NIHR Med-Tech Cooperative to support the translation of the probe towards clinical measurement.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -