Aptamer-based cocaine assay using a nanohybrid composed of ZnS/Ag2Se quantum dots, graphene oxide and gold nanoparticles as a fluorescent probe
- Submitting institution
-
University of Dundee
- Unit of assessment
- 12 - Engineering
- Output identifier
- 48560655
- Type
- D - Journal article
- DOI
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10.1007/s00604-019-4101-6
- Title of journal
- Microchimica Acta
- Article number
- 104
- First page
- -
- Volume
- 187
- Issue
- 2
- ISSN
- 0026-3672
- Open access status
- Compliant
- Month of publication
- January
- Year of publication
- 2020
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- 8 - Chemistry
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- Yes
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
4
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Abuse of cocaine remains a critical public health challenge because of the associated health risks of its illicit use. Aptamers are single-stranded synthetic DNA or RNA oligonucleotide sequences that selectively bind to a target analyte via shape recognition and are used in biosensing applications. This paper presents a novel aptamer-based nanoprobes with low detection limit, excellent selectivity, and rapid response time for detection of cocaine. Furthermore, the application of nanoprobes to detect seized adulterated cocaine was successfully achieved. This work was supported by grants from the Leverhulme Trust (Leverhulme Research Centre for Forensic Science) and EPSRC (EP/P008135/2 and EP/S017445/1).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -