Development of [18F]FAMTO: A novel fluorine-18 labelled positron emission tomography (PET) radiotracer for imaging CYP11B1 and CYP11B2 enzymes in adrenal glands
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 101276170
- Type
- D - Journal article
- DOI
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10.1016/j.nucmedbio.2018.11.002
- Title of journal
- Nuclear Medicine and Biology
- Article number
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- First page
- 14
- Volume
- 68-69
- Issue
- -
- ISSN
- 0969-8051
- Open access status
- Compliant
- Month of publication
- November
- Year of publication
- 2018
- URL
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- Supplementary information
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- Request cross-referral to
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- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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7
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This reports the first 18F-labelled CYB11B tracer for diagnosing aldosterone-secreting kidney adenomas from bilateral disease. These tumours account for 6–15% of hypertension cases – patients could be cured of life-long hypertension by keyhole surgery if they could be reliably identified [doi.org/10.1007/s12020-020-02474-3]. Current diagnostics are invasive and as such not widely used. This paper describes the synthesis and characterisation of 18F-FAMTO which can make a non-invasive diagnostic radiotracer availabie at most PET scanners remote from cyclotron production centres for patient stratification for curative hypertension surgery. The paper won the journal's best publication award for 2019 https://doi.org/10.1016/j.nucmedbio.2018.11.002
- Author contribution statement
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- Non-English
- No
- English abstract
- -
