GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment
- Submitting institution
-
Queen Mary University of London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 644
- Type
- D - Journal article
- DOI
-
10.15252/embr.201846556
- Title of journal
- EMBO Reports
- Article number
- ARTN e46556
- First page
- -
- Volume
- 20
- Issue
- 1
- ISSN
- 1469-221X
- Open access status
- Compliant
- Month of publication
- December
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
7
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Funded from ERC grant (282051-€1.99M) and BBSRC (BB/N018532/1-£429k) this study presents a novel concept of tamoxifen as a regulator of the tumour microenvironment via GPER. EMBO reports cover to highlight this work and the accompanying back-to-back manuscript (http://embor.embopress.org/content/20/1.cover-expansion). News and Views: (i) http://embor.embopress.org/content/20/1/e47334, (ii) https://erc.europa.eu/projects-figures/stories/new-weapon-against-pancreatic-cancer-way. Trends in Cancer commissioned an editorial about this work. On World Cancer Day our research was one of the two featured stories selected by ERC Europe (https://twitter.com/ERC_Research/status/1092411708163932160). Contributed to PhD award for Lachowski and Rice and appointment to academic position for Thorpe (University College Dublin). ERC proof of concept MechanoGPER awarded (https://cordis.europa.eu/project/id/874581) to develop impact.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -