Application of a Demineralized Cortical Bone Matrix and Bone Marrow-Derived Mesenchymal Stem Cells in a Model of Chronic Rotator Cuff Degeneration
- Submitting institution
-
University College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 12345
- Type
- D - Journal article
- DOI
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10.1177/0363546517727512
- Title of journal
- The American Journal of Sports Medicine
- Article number
- -
- First page
- 98
- Volume
- 46
- Issue
- 1
- ISSN
- 0363-5465
- Open access status
- Compliant
- Month of publication
- September
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper reports the use of demineralised bone matrix and stem cells (BDM/MSCs) for augmenting healing of chronic rotator cuff degeneration; a debilitating shoulder tendon/bone condition that effects 25% of the adult population and has a significant negative impact on patient quality of life and the global socioeconomic environment. In our clinically representative animal model, DBM/MSCs restored bone quality to preinjury levels by 6 weeks, hence has potential to improve the human clinical problem. The findings from this paper supported successful applications for one PhD and one MSc student, and a total of £130,150 funding to further the research.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -