Acoustic wave sparsely activated localization microscopy (AWSALM) : Super-resolution ultrasound imaging using acoustic activation and deactivation of nanodroplets
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 124905532
- Type
- D - Journal article
- DOI
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10.1063/1.5029874
- Title of journal
- APPLIED PHYSICS LETTERS
- Article number
- 014101
- First page
- -
- Volume
- 113
- Issue
- 1
- ISSN
- 0003-6951
- Open access status
- Compliant
- Month of publication
- July
- Year of publication
- 2018
- URL
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- Supplementary information
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- Request cross-referral to
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- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
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- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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8
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Photo-activated localization microscopy (PALM) has revolutionised the field of fluorescence microscopy by breaking the diffraction-limit in spatial resolution. In this work, an acoustic counterpart of PALM is introduced as acoustic wave sparsely activated localization microscopy (AWSALM), and is demonstrated experimentally to super-resolve structures beyond the conventional limit. This new technique is flow independent and considerably faster than existing ultrasound super-resolution techniques. This resulted in several further important contributions (10.1109/TUFFC.2019.2906496, 10.1109/ULTSYM.2019.8926069, 10.1109/ULTSYM.2019.8926067, 10.1109/ULTSYM.2019.8926179, 10.1109/ULTSYM.2019.8925892, 10.1109/IUS46767.2020.9251478), successful grant funding (EP/T008970/1), and provided the basis for a 3D, fast nanodroplet work-package within a MRC Career Development Award Fellowship (MR/S023542/1) awarded to Dr Christensen-Jeffries.
- Author contribution statement
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- Non-English
- No
- English abstract
- -