Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA
- Submitting institution
-
The University of Sheffield
- Unit of assessment
- 12 - Engineering
- Output identifier
- 2748
- Type
- D - Journal article
- DOI
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10.1261/rna.045138.114
- Title of journal
- RNA
- Article number
- -
- First page
- 347
- Volume
- 21
- Issue
- 3
- ISSN
- 1355-8382
- Open access status
- Out of scope for open access requirements
- Month of publication
- January
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
11
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This multidisciplinary-BBSRC funded work (BB/D011795/1) was performed in collaboration with an international industrial partner (Phynexus) and developed novel open tube capillaries for bioseparations. This paper is the first ever study to demonstrate that arginine methylation and citrullination can regulate the mRNA binding of proteins. As RNA binding proteins are associated with a wide range of human diseases, this work will facilitate the identification of new therapeutic targets for treatment of disorders including: metabolic disorders/neurological disease/ cancer and ultimately lead to new drug therapies. This work was instrumental in obtaining further funding from the BBSRC (BB/M012166/1).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
