Assessment of myocardial microstructural dynamics by in vivo diffusion tensor cardiac magnetic resonance
- Submitting institution
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Nottingham Trent University
- Unit of assessment
- 12 - Engineering
- Output identifier
- 14 - 696267
- Type
- D - Journal article
- DOI
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10.1016/j.jacc.2016.11.051
- Title of journal
- Journal of the American College of Cardiology
- Article number
- S0735109716373272
- First page
- 661
- Volume
- 69
- Issue
- 6
- ISSN
- 0735-1097
- Open access status
- Compliant
- Month of publication
- February
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- 3 - Allied Health Professions, Dentistry, Nursing and Pharmacy
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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17
- Research group(s)
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A - Imaging, Materials and Engineering Centre
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper improved medical knowledge competence by showing that the myocardial sheetlet function, as measured by non-invasive DT-CMR, is the predominant microstructural mechanism responsible for contractile wall thickening. The output laid the groundwork for a BHF grant (RG/19/1/34160, total: £1.5m), which coupled with the support from Siemens and most co-authors’ affiliations to NHS and NIH have all been safeguarding the method’s translation to clinical practice. Further developments are that several clinical studies have applied the technique to understand the pathogenesis and response to therapeutic interventions in patients with dilated and hypertrophic cardiomyopathy, situs inversus totalis, cardiac amyloidosis, and aortic stenosis.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -