Mathematical modelling of fluid flow and solute transport to define operating parameters for in vitro perfusion cell culture systems
- Submitting institution
-
Liverpool John Moores University
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 1411
- Type
- D - Journal article
- DOI
-
10.1098/rsfs.2019.0045
- Title of journal
- Interface Focus
- Article number
- 20190045
- First page
- -
- Volume
- 10
- Issue
- 2
- ISSN
- 2042-8898
- Open access status
- Compliant
- Month of publication
- February
- Year of publication
- 2020
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
5
- Research group(s)
-
-
- Citation count
- 2
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This work uses novel 3D numerical modelling to characterise fluid flow and solute transport in a widely-used commercially available perfusion bioreactor. The use of this system has been hindered by a lack of understanding of the physical and chemical environment that the cells are exposed to. However, this work provides insight on these features and describes how the model may used by experimentalists to define operating parameters for their particular perfusion system, and highlights operating conditions that should be avoided.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
