Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN
- Submitting institution
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The University of Surrey
- Unit of assessment
- 12 - Engineering
- Output identifier
- 9023101_1
- Type
- D - Journal article
- DOI
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10.1038/s41598-019-47463-3
- Title of journal
- Scientific Reports
- Article number
- 10884
- First page
- -
- Volume
- 9
- Issue
- 1
- ISSN
- 2045-2322
- Open access status
- Compliant
- Month of publication
- -
- Year of publication
- 2019
- URL
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-
- Supplementary information
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- Request cross-referral to
- 9 - Physics
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
-
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- The innovative use of ‘spare protons’ from an advanced particle accelerator (CERN) on tantalum targets, combined with a bespoke radiochemical separation procedure allowed us to obtain a high purity 155Tb source, representing the world’s first primary standard of the isotope for medical applications and improved nuclear data. The product was supplied to Lausanne University Hospital for successful radiolabelling to a monoclonal antibody suitable for pre-clinical trials. Subsequent separation of terbium from bulk gadolinium targets irradiated at synchrotron facilities opens the route to widespread uptake of the method and greatly improved access to theranostic lanthanides worldwide.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -