Combined sonodynamic and antimetabolite therapy for the improved treatment of pancreatic cancer using oxygen loaded microbubbles as a delivery vehicle.
- Submitting institution
-
University of Oxford
- Unit of assessment
- 12 - Engineering
- Output identifier
- 9535
- Type
- D - Journal article
- DOI
-
10.1016/j.biomaterials.2015.11.033
- Title of journal
- Biomaterials
- Article number
- -
- First page
- 20
- Volume
- 80
- Issue
- -
- ISSN
- 0142-9612
- Open access status
- Out of scope for open access requirements
- Month of publication
- November
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
https://ars.els-cdn.com/content/image/1-s2.0-S0142961215009370-mmc1.docx
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
11
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This research has formed the basis for 2 patents (GB1520649, GB1708663) and a spin-out company founded in 2018 (SonoTarg Ltd.) which has raised GBP1,400,000 to undertake a first-in-human clinical trial in 2021. It has been the subject of invited talks at The British Medical Ultrasound Society 2017, The Royal Society of Medicine Medical Innovation Summit 2017, New Scientist Live 2016 and Wired Live 2017. It has led to further funding from The Pancreatic Cancer Research Fund and the EPSRC Impact Acceleration Scheme (EP/R511742/1). It was also the subject of an article in Nature (10.1038/d41586-019-00906-3).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -