Epigenetic Profile of Human Adventitial Progenitor Cells Correlates With Therapeutic Outcomes in a Mouse Model of Limb Ischemia
- Submitting institution
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University of Brighton
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 7123751
- Type
- D - Journal article
- DOI
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10.1161/ATVBAHA.114.304989
- Title of journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Article number
- -
- First page
- 675
- Volume
- 35
- Issue
- 3
- ISSN
- 1079-5642
- Open access status
- Out of scope for open access requirements
- Month of publication
- January
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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22
- Research group(s)
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-
- Citation count
- 30
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Understanding the association between the functional, epigenetic, and expressional profile of human adventitial progenitor cells (APCs) and therapeutic activity in a model of limb ischemia allows the cells to be refined to treat ischemic heart disease. This paper is significant because it demonstrates that (a) DNA methylation landscape illustrates different therapeutic activities of human APCs, (b) there is potential for epigenetic screening to help guide cell-based vascular therapeutics. The findings of the paper are now well established and cited in review articles including Psaltis and Simari (Circulation Research 2015) and Ferland-McCollough et al. (Pharm. and Thera. 2015).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -