A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 83148847
- Type
- D - Journal article
- DOI
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10.1016/j.yjmcc.2017.03.008
- Title of journal
- Journal of Molecular and Cellular Cardiology
- Article number
- -
- First page
- 68
- Volume
- 106
- Issue
- 0
- ISSN
- 0022-2828
- Open access status
- Not compliant
- Month of publication
- April
- Year of publication
- 2017
- URL
-
-
- Supplementary information
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- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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5
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Cellular contraction is crucial to cardiac pump function. Patient-specific computer models of the heart can integrate data, investigate multi-scale function and predict patient outcomes to deliver precision medicine. This paper experimentally measured and developed the first biophysical model of cellular contraction in human myocardium. For transparency and rigor, the model code and the data collected were made publicly available (http://cemrg.com/models.html). This work is being used for simulation of patient specific models, drug screening and studying basic cardiology in Europe (https://pubmed.ncbi.nlm.nih.gov/32710902/) and America (https://pubmed.ncbi.nlm.nih.gov/28851517/), and led to the funding of a BHF programme grant (RG/20/4/34803) and an ERC consolidator award (864055).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -