Mathematical modelling indicates that lower activity of the haemostatic system in neonates is primarily due to lower prothrombin concentration
- Submitting institution
-
Liverpool John Moores University
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 1057
- Type
- D - Journal article
- DOI
-
10.1038/s41598-019-40435-7
- Title of journal
- Scientific Reports
- Article number
- 3936
- First page
- -
- Volume
- 9
- Issue
- 1
- ISSN
- 2045-2322
- Open access status
- Compliant
- Month of publication
- March
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
5
- Research group(s)
-
-
- Citation count
- 4
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Although it is well-known that the coagulation system undergoes considerable age-dependent changes, a mathematical model accounting for differences between neonates, children, teenagers and adults has so far been unavailable. This study closes this gap using a unique age-stratified data set comprising the concentrations of key coagulation proteins for different age groups. This model is currently used for investigating treatments for young patients based on an enhanced understanding of age-dependent changes of coagulation.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
