Calcium phosphate thin films enhance the response of human mesenchymal stem cells to nanostructured titanium surfaces
- Submitting institution
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University of Ulster
- Unit of assessment
- 12 - Engineering
- Output identifier
- 76464765
- Type
- D - Journal article
- DOI
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10.1177/2041731414537513
- Title of journal
- Journal of Tissue Engineering
- Article number
- -
- First page
- 1
- Volume
- 5
- Issue
- -
- ISSN
- 2041-7314
- Open access status
- Out of scope for open access requirements
- Month of publication
- May
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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2
- Research group(s)
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C - Biomaterials and Tissue Engineering
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Mesenchymal stem cells continue to provide the key cellular source for connective tissue regenerative medicine and tissue engineering applications. Here, nanostructured biomaterials successfully provide essential topography, surface chemistry and mechanical stiffness to promote stem cell osteogenesis and significant potential for the development of orthopaedic biomaterials for joint replacement and bone cements. As well as making a valuable contribution to the rapidly growing literature on nano-topographical substrates on stem cell adhesion, differentiation and apoptosis, this research informed successful patent applications (EU – 2736544, US - 9463082) and a proof-of-concept award (£93K) used to successfully create electrospun polymers for 3D tissue engineering.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -