Cell shape and the microenvironment regulate nuclear translocation of NF-κB in breast epithelial and tumor cells.
- Submitting institution
-
University of Oxford
- Unit of assessment
- 12 - Engineering
- Output identifier
- 9570
- Type
- D - Journal article
- DOI
-
10.15252/msb.20145644
- Title of journal
- Molecular systems biology
- Article number
- -
- First page
- 790
- Volume
- 11
- Issue
- 3
- ISSN
- 1744-4292
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
https://www.embopress.org/action/downloadSupplement?doi=10.15252%2Fmsb.20145644&file=msb145644-sup-0014-suppl_info.docx
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Published in a leading journal for systems biology, this study proposed a novel framework combining computer vision approaches and statistical modelling to characterise the relationship between the cell context and gene activity. This study showed the importance of cell context in modulating the activity of key cancer genes in breast cancer cells. Based on the results and findings of this work, a further study was performed and published in Genome Research (10.1101/gr.202028.115).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -