A novel in vivo receptor occupancy methodology for the glucocorticoid receptor : towards an improved understanding of lung PK/PD
- Submitting institution
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The University of Warwick
- Unit of assessment
- 12 - Engineering
- Output identifier
- 7659
- Type
- D - Journal article
- DOI
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10.1124/jpet.114.221226
- Title of journal
- Journal of Pharmacology and Experimental Therapeutics
- Article number
- -
- First page
- 279
- Volume
- 353
- Issue
- 2
- ISSN
- 1521-0103
- Open access status
- Out of scope for open access requirements
- Month of publication
- February
- Year of publication
- 2015
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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6
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- A new method for measuring receptor occupancy in drug inhalation studies is provided. These studies are used to understand and characterise how the body handles a drug and its subsequent effects. This method has been adopted into industrial practice by AstraZeneca (contact: Markus.Friden@astrazeneca.com). The first author, a PhD student funded through Marie Curie European Industrial Doctorate scheme, won the Warwick science faculty thesis prize, was awarded "breakthrough scientist of the year" in the AstraZeneca Science Awards 2015 for her work within the field of inhalation pharmacokinetics, and was employed by AstraZeneca (industrial partner) on completion.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -