A spatially-averaged mathematical model of kidney morphogenesis
- Submitting institution
-
University of Brighton
- Unit of assessment
- 12 - Engineering
- Output identifier
- 7123975
- Type
- D - Journal article
- DOI
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10.1016/j.jtbi.2015.04.015
- Title of journal
- Journal of Theoretical Biology
- Article number
- -
- First page
- 24
- Volume
- 379
- Issue
- -
- ISSN
- 0022-5193
- Open access status
- Out of scope for open access requirements
- Month of publication
- April
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
7
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Despite branching morphogenesis playing a determining role in the kidneys’ ability to filter waste products, this process is still not well understood. This paper is significant because it proposed a new time-dependent mathematical model of kidney organogenesis that can be used to predict final branch generation number within the developing kidney. This model was used to predict the final branch generation number both under normal conditions and in response to perturbations, to explain for the first time why the kidney development is resistant to loss of ureteric tip cells, but not to the damage of cap mesenchyme cells.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -