Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46) : an epidemiological study
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 136868969
- Type
- D - Journal article
- DOI
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10.1016/S1474-4422(19)30228-5
- Title of journal
- Lancet Neurology
- Article number
- -
- First page
- 942
- Volume
- 18
- Issue
- 10
- ISSN
- 1474-4422
- Open access status
- Compliant
- Month of publication
- August
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
24
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This study extracted and analysed data from 465 cognitively normal patients aged 69-71, all members of a national epidemiologic study, the MRC NSHD/1946BC. It aimed at identifying a link between blood pressure changes in adulthood and alteration in brain structure or development of pathologies in late life. Using a unique design, this study presented the first work examining blood pressure measurements from early adulthood into midlife to late life and explored their effect on future brain pathology. The result suggests that early monitoring and control of blood pressure might impact positively in brain health later in life.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
