Bismuth embedded silica nanoparticles loaded with autophagy suppressant to promote photothermal therapy
- Submitting institution
-
University College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 12701
- Type
- D - Journal article
- DOI
-
10.1016/j.biomaterials.2019.119419
- Title of journal
- Biomaterials
- Article number
- ARTN 119419
- First page
- -
- Volume
- 221
- Issue
- -
- ISSN
- 0142-9612
- Open access status
- Compliant
- Month of publication
- August
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
https://ars.els-cdn.com/content/image/1-s2.0-S0142961219305186-mmc1.docx
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
8
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- The paper describes the development of an advanced nanomaterial based platform to overcome the resistance of tumour cells to photo-thermia in photo thermal therapy (PTT). Embedding of a new 'green metal' bismuth into mesoporous silica nanoparticles is able to suppress the resistance by controlling the delivery of an autophagy inhibitor. The work demonstrates strong international and interdisciplinary research collaborations in developing robust therapies with improved therapeutic efficacy in oncology, which won the support of the Education Ministry of China for a 5 year research collaboration program (B16043), National Nature Science Foundation (51672247) and Central Universities Fundamental Research Funds (2019XZZX005-3-01, 2016YFC1101900).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -