Transition between encoding and consolidation / replay dynamics via cholinergic modulation of CAN current: a modeling study
- Submitting institution
-
University of Lincoln
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 27738
- Type
- D - Journal article
- DOI
-
10.1002/hipo.22429
- Title of journal
- Hippocampus
- Article number
- -
- First page
- 1052
- Volume
- 25
- Issue
- 9
- ISSN
- 1050-9631
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2015
- URL
-
https://doi.org/10.1002/hipo.22429
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
6
- Research group(s)
-
-
- Citation count
- 7
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This research demonstrated groundbreaking evidence of how switching between encoding and consolidation/replay of memories takes place in hippocampus. It identified for the first time that the cellular signature (mechanism) responsible for the transition between encoding and consolidation/replay modes is the cholinergic (acetylcholine) modulation of the CAN current. Increase in CAN conductance via ACh promotes encoding of memories, whereas elimination of CAN current via ACh promotes replay/consolidation of memories.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -