Porous yolk-shell particle engineering via nonsolvent-assisted trineedle coaxial electrospraying for burn-related wound healing
- Submitting institution
-
University of Ulster
- Unit of assessment
- 12 - Engineering
- Output identifier
- 77548086
- Type
- D - Journal article
- DOI
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10.1021/acsami.8b22112
- Title of journal
- ACS Applied Materials and Interfaces
- Article number
- -
- First page
- 7823
- Volume
- 11
- Issue
- 8
- ISSN
- 1944-8244
- Open access status
- Deposit exception
- Month of publication
- February
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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6
- Research group(s)
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C - Biomaterials and Tissue Engineering
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- The work shows a significant and novel approachs to producing multi-functional porous yolk-shell particles (YSPs) produced via a single-step tri-needle co-axial electro-spraying. TiO2-Ag nanoparticles and GLP were encapsulated into the outer shell of YSPs as the major antibacterial and antioxidant component, while iron oxide (Fe3O4) nanoparticles were incorporated into the inner core to act as a photothermal agent. In-vivo wound healing on a burn wound model (c57 murine line) is improved based on YSPs and laser-assisted therapy. The method allows the engineering of multi-functional porous YSPs for natural and synthetic medicinal actives and their hosting dosages in a single step.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -