Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose
- Submitting institution
-
University of Keele
- Unit of assessment
- 12 - Engineering
- Output identifier
- 384
- Type
- D - Journal article
- DOI
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10.1016/j.cmet.2016.06.020
- Title of journal
- Cell Metabolism
- Article number
- -
- First page
- 389
- Volume
- 24
- Issue
- 3
- ISSN
- 1550-4131
- Open access status
- Compliant
- Month of publication
- July
- Year of publication
- 2016
- URL
-
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30306-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413116303060%3Fshowall%3Dtrue
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
16
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This study showed that specialized hubs, identified as 1%–10% of beta cells with more active mitochondria and less insulin, synchronize beta cell oscillations. It involved researchers from nine institutions based in the UK, Germany, Italy and Switzerland. It was featured in a Cell Metabolism Editorial (2016, 24, 371-372) as well as in 26 news stories from 17 different media outlets. The work has been presented at multiple international conferences, including an invited talk at the 2016 Molecular Sensors and Logic Gates meeting in Bath. It also contributed to a recently funded EPSRC-SFI project (EP/T007397/1).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
