Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy
- Submitting institution
-
Abertay University
- Unit of assessment
- 12 - Engineering
- Output identifier
- 17561537
- Type
- D - Journal article
- DOI
-
10.3390/cells3020563
- Title of journal
- Cells
- Article number
- -
- First page
- 563
- Volume
- 3
- Issue
- 2
- ISSN
- 2073-4409
- Open access status
- Out of scope for open access requirements
- Month of publication
- June
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
8
- Research group(s)
-
D - Modelling & Simulation
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper focuses on single and combination anti-cancer drug therapies and mechanisms of action in order to overcome drug resistance. Through a combination of in silico, in vitro and in vivo systems we are able to show synergistic effects to two anti-cancer drugs achieved through drug-induced network reprogramming. An understanding of mechanisms of anti-cancer drug resistance in the context of relative HER2 and HER3 expression remains an important contribution to combination therapies and precision medicine, and the research is referenced in subsequent experimental results and review publications as recently as 2020 and 2021 respectively.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
