Human Fetal Osteoblast Response on Poly(Methyl Methacrylate)/Polystyrene Demixed Thin Film Blends: Surface Chemistry Vs Topography Effects
- Submitting institution
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University of Ulster
- Unit of assessment
- 12 - Engineering
- Output identifier
- 76491029
- Type
- D - Journal article
- DOI
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10.1021/acsami.5b08073
- Title of journal
- ACS Applied Materials & Interfaces
- Article number
- -
- First page
- 14920
- Volume
- 8
- Issue
- -
- ISSN
- 1944-8244
- Open access status
- Out of scope for open access requirements
- Month of publication
- December
- Year of publication
- 2015
- URL
-
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- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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3
- Research group(s)
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C - Biomaterials and Tissue Engineering
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper provides a new methodology to enable discrimination between the chemical and topographical effects of a material surface on attendant in vitro osteoblast cell response. The results provide a new understanding of how PS/PMMA spin-coated polymer de-mixed solutions can create a pronounced a micro/nano-scale topography which has a pure PMMA chemistry such that the role of the former can be isolated experimentally. The work was funded in part from a £4.2M EPSRC Grand Challenge Award (EP/C534247/1) - “Regenerative Medicine – A New Industry (Remedi)” (Core collaborators: Universities of Loughborough, Nottingham, Ulster, Cambridge, Birmingham, and Liverpool).
- Author contribution statement
- -
- Non-English
- No
- English abstract
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