Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model
- Submitting institution
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Queen Mary University of London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 705
- Type
- D - Journal article
- DOI
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10.1038/s41467-019-12067-y
- Title of journal
- Nature Communications
- Article number
- ARTN 4072
- First page
- 4072
- Volume
- 10
- Issue
- 1
- ISSN
- 2041-1723
- Open access status
- Compliant
- Month of publication
- September
- Year of publication
- 2019
- URL
-
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- Supplementary information
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- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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8
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- The mechanosensitive polycystin-2 channel was known to be important for kidney health however this paper is first to show that expression on primary cilia is necessary to prevent polycystic kidney disease. This work funded by two Medical Research Council Grants (MC_U142670370, MR/L002876/1) helped secure an EPSRC/CRUK grant on cilia signalling (£265k, C56133/A29455). The output supported a PhD completion and led to a prestigious PKD Foundation post-doc Fellowship (Walker: University of Maryland). It also led to an invitation to co-author a Nature Reviews Nephrology paper (https://www.nature.com/articles/s41581-020-00342-x) and supported Knight/Norris leading the UK Cilia Network (>400 members with regular international symposia, www.cilianetwork.org.uk).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -