A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity
- Submitting institution
-
The University of Leeds
- Unit of assessment
- 12 - Engineering
- Output identifier
- CHEM-2
- Type
- D - Journal article
- DOI
-
10.1016/j.nano.2013.12.011
- Title of journal
- Nanomedicine: Nanotechnology, Biology and Medicine
- Article number
- -
- First page
- 1529
- Volume
- 10
- Issue
- 7
- ISSN
- 1549-9634
- Open access status
- Out of scope for open access requirements
- Month of publication
- January
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
https://ars.els-cdn.com/content/image/1-s2.0-S1549963413007764-mmc1.docx
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
9
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Iron-deficiency anaemia is the largest nutritional deficiency disorder in the world. Supplement-based treatments typically rely on soluble iron salts, which can cause side effects including diarrhoea, constipation and gastro-intestinal inflammation. This paper describes an original concept, to mimic ferritin molecule mineral cores in terms of stability, safety and bioavailability, and won Royal Society of Chemistry’s Emerging Technologies 2014 competition. It is patented (WO/2017/060441) and has undergone a pivotal paediatric clinical trial in Gambia, funded by the Gates Foundation (IHAT-Gut, NCT02941081), and is now licensed to Nemysis Ltd who are seeking European Food Safety Authority approval for use as a supplement.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
