Chromosome-free bacterial cells are safe and programmable platforms for synthetic biology
- Submitting institution
-
University of Oxford
- Unit of assessment
- 12 - Engineering
- Output identifier
- 9577
- Type
- D - Journal article
- DOI
-
10.1073/pnas.1918859117
- Title of journal
- Proceedings of the National Academy of Sciences
- Article number
- -
- First page
- 6752
- Volume
- 117
- Issue
- 12
- ISSN
- 0027-8424
- Open access status
- Compliant
- Month of publication
- March
- Year of publication
- 2020
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
14
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- The groundbreaking paper presented the concept of SimCells (Simple Cells) as a reprogrammable chassis for synthetic biology as single cell factories. SimCells, derived from natural bacteria, are artificial cellular machine to express designed gene-circuits. This very first paper demonstrated that the designed SimCells were safe and smart agents for cancer treatment. The results laid foundations for future advances in synthetic biology.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -