Continuous-Flow Sonocrystallization in Droplet-Based Microfluidics
- Submitting institution
-
Manchester Metropolitan University
- Unit of assessment
- 12 - Engineering
- Output identifier
- 2406
- Type
- D - Journal article
- DOI
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10.1021/acs.cgd.5b01153
- Title of journal
- Crystal Growth & Design
- Article number
- -
- First page
- 5519
- Volume
- 15
- Issue
- 11
- ISSN
- 1528-7483
- Open access status
- Out of scope for open access requirements
- Month of publication
- October
- Year of publication
- 2015
- URL
-
http://doi.org/10.1021/acs.cgd.5b01153
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
5
- Research group(s)
-
C - Smart Infrastructure
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Despite several challenges in handling micron-size solid particles in small-scale flows, in a multidisciplinary collaboration between chemical, process and mechanical engineers, for the first time, a novel millifluidic continuous-flow reactor was developed and tested. The reactor used ultrasound technology to produce pharmaceutical ingredients. This continuous sonocrystallization device attracted GSK for a collaboration on scaling-up the idea (chris.price@strath.ac.uk) and led to initiation of an EPSRC proposal. Moreover, Process Systems Enterprise Ltd (Sean Bermingham:https://www.psenterprise.com/bu/formulated-products/key-personnel) as the world-leading company in developing modelling tools for chemical processes supported the idea presented in this paper to further develop the design.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -