Cerebellar output controls generalized spike-and-wave discharge occurence
- Submitting institution
-
University of Hertfordshire
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 13603743
- Type
- D - Journal article
- DOI
-
10.1002/ana.24399
- Title of journal
- Annals of Neurology
- Article number
- -
- First page
- 1027
- Volume
- 77
- Issue
- 6
- ISSN
- 0364-5134
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
15
- Research group(s)
-
-
- Citation count
- 60
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- First computational study that applies machine learning to show that cerebellar neurons can participate in epileptic seizures. The automated detection of epileptic seizures allows their termination in a closed-loop system in mice. Potential applications for the termination of seizures in children are currently being explored together with Prof Hoebeek at the University of Utrecht. The work has inspired a successful application for a Veni grant by Dr Kros at Erasmus Medical Center Rotterdam (with UH as named collaborator) and a computational study of the termination of epileptic activity that won the best poster prize at the CNS*2019 conference in Barcelona.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -