Bleb-driven chemotaxis of Dictyostelium cells
- Submitting institution
-
The University of Warwick
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 5877
- Type
- D - Journal article
- DOI
-
10.1083/jcb.201306147
- Title of journal
- The Journal of Cell Biology
- Article number
- -
- First page
- 1027
- Volume
- 204
- Issue
- 6
- ISSN
- 0021-9525
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- 5 - Biological Sciences
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
3
- Research group(s)
-
A - Applied Computing
- Citation count
- 61
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This interdisciplinary work published in an eminent cell biological journal involved new developments for our QuimP software (go.warwick.ac.uk/quimp), which were crucially applied to automatically track and characterise different forms of cell membrane protrusions during cell migration. This research adds significantly to our knowledge how blebs, one particular type of protrusions, are triggered in response to extracellular chemical signals, relevant to cell motility in cancer and cell invasion. High-quality follow-up papers on developing theoretical models for blebbing (DOI:10.1073/pnas.1322291111) and fitting them to experimental data (DOI:10.1038/s41598-017-06875-9), lead up to BBSRC funding (BB/R004579/1) for extending our work to 3D light-sheet microscopy data.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -