Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action
- Submitting institution
-
University of York
- Unit of assessment
- 12 - Engineering
- Output identifier
- 66292140
- Type
- D - Journal article
- DOI
-
10.1038/srep41206
- Title of journal
- Scientific Reports
- Article number
- 41206
- First page
- -
- Volume
- 7
- Issue
- -
- ISSN
- 2045-2322
- Open access status
- Compliant
- Month of publication
- February
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
7
- Research group(s)
-
B - Intelligent Systems and Nano-Science
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- The first use of nano-mechanical sensors to differentiate the efficacy of a new antibiotic oritavancin from the current last defence antibiotic vancomycin. The work led to large media interest due to the its impact on the global challenge of Antimicrobial Resistance (AMR), e.g. https://www.thesun.co.uk/living/2779580/scientists-discover-how-to-supercharge-antibiotics-to-blow-up-deadly-superbugs/. Results from this work supported FDA approval for the antibiotic drug oritavancin developed by Targanta Therapeutics Corporation now acquired The Medicines Company (Contact: Company contact). The work was partially supported by Targanta Therapeutics Corporation.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -