An Ultra Scale-Down Analysis of the Recovery by Dead-End Centrifugation of Human Cells for Therapy
- Submitting institution
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University College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 11987
- Type
- D - Journal article
- DOI
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10.1002/bit.25519
- Title of journal
- BIOTECHNOLOGY AND BIOENGINEERING
- Article number
- -
- First page
- 997
- Volume
- 112
- Issue
- 5
- ISSN
- 0006-3592
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2015
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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3
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This first introduction of engineering rigour into the laboratory-scale preparation of human cell therapies identified the key reason for serious cell damage and provided the means to ensure reproducibility and high yields when turning from laboratory research to manufacture. This was demonstrated by application to ReNeuron clinical candidates for stroke repair and underpinned £274k EPSRC-Reneuron EngDs to study bioprocessing of novel human cell therapy products. The completion of a portfolio of USD studies (eg https://doi.org/10.1002/bit.26257) provides the foundation for the engineering design of cell-therapy manufacture. The lead researcher now manages cell recovery studies in the UK Cell Therapy Catapult.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -