An activation-repolarization time metric to predict localized regions of high susceptibility to reentry
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 97965491
- Type
- D - Journal article
- DOI
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10.1016/j.hrthm.2015.04.013
- Title of journal
- Heart rhythm : the official journal of the Heart Rhythm Society
- Article number
- -
- First page
- 1644
- Volume
- 12
- Issue
- 7
- ISSN
- 1547-5271
- Open access status
- Out of scope for open access requirements
- Month of publication
- April
- Year of publication
- 2015
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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13
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This work describes a novel clinical electroanatomical mapping procedure to more accurately, and safely, identify ablation targets in patients suffering incessant arrhythmias. Comprehensive biophysically-accurate computational modelling was combined with ex-vivo experimental optical mapping validation (in sheep) and clinical measurements to demonstrate the utility of this novel mapping procedure and associated metric. This has directly led to a BHF Project Grant (PG/16/81/32441) involving further computational optimisation of the algorithm [doi.org/10.1016/j.compbiomed.2019.03.018] and a proof-of-concept clinical study. Current widespread clinical enthusiasm and uptake (Editorial: 10.1016/j.ijcard.2018.06.058) has led to a formal agreement with Boston Scientific to support further development (tobias.Oesterlein@bsci.com).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -