Three-Dimensional Electrohydrodynamic Printing and Spinning of Flexible Composite Structures for Oral Multidrug Forms
- Submitting institution
-
University of Ulster
- Unit of assessment
- 12 - Engineering
- Output identifier
- 77548095
- Type
- D - Journal article
- DOI
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10.1021/acsami.8b08880
- Title of journal
- ACS Applied Materials and Interfaces
- Article number
- -
- First page
- 24876
- Volume
- 10
- Issue
- 29
- ISSN
- 1944-8244
- Open access status
- Deposit exception
- Month of publication
- June
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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3
- Research group(s)
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C - Biomaterials and Tissue Engineering
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper shows a new method to rapidly customise flexible composite structures for oral multi-drug dosage forms, and how integrated herbal extracts and conventional active agents can be precisely fabricated in a single capsule via high precision 3D EHD printing. These separable flexible membranes can be triggered as the interlayer dissolves, thus providing longer continuous drug dosing in gastrointestinal tract. Both hydrophilic and hydrophobic drugs can be independently released in controllable manner for personalized therapeutic dosing, which enable tangible multi-stage improvements in healthcare. This work and international invention (CN201810300530.6) were achieved by an international corporation (US, UK and China).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -