Atomic Layer Deposition of a Silver Nanolayer on Advanced Titanium Orthopedic Implants Inhibits Bacterial Colonization and Supports Vascularized de Novo Bone Ingrowth
- Submitting institution
-
The Open University
- Unit of assessment
- 12 - Engineering
- Output identifier
- 1564324
- Type
- D - Journal article
- DOI
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10.1002/adhm.201700033
- Title of journal
- Advanced Healthcare Materials
- Article number
- 1700033
- First page
- -
- Volume
- 6
- Issue
- 11
- ISSN
- 2192-2640
- Open access status
- Compliant
- Month of publication
- March
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
9
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Joint replacement surgery is associated with significant morbidity and mortality following infection with either methicillin-resistant Staphylococcus aureus (MRSA) or Staphylococcus epidermidis. These organisms have strong biofilm-forming capability in deep wounds and on prosthetic surfaces. To inhibit biofilm formation, we developed 3D titanium structures coated with a silver nanolayer. S. epidermidis demonstrated significant reductions in bacterial recovery (p < 0.0001) and biofilm formation (p < 0.001) on the silver-coated structures. We conclude that nanolayer silver of titanium implants reduces pathogenic biofilm formation in vitro and facilitates vascularization and osseointegration in vivo, making this a promising technique for clinical orthopaedic applications.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
