Mass and controlled fabrication of aligned PVP fibers for matrix type antibiotic drug delivery systems
- Submitting institution
-
University of Ulster
- Unit of assessment
- 12 - Engineering
- Output identifier
- 77548125
- Type
- D - Journal article
- DOI
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10.1016/j.cej.2016.08.135
- Title of journal
- Chemical Engineering Journal
- Article number
- -
- First page
- 661
- Volume
- 307
- Issue
- -
- ISSN
- 1385-8947
- Open access status
- Deposit exception
- Month of publication
- August
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
4
- Research group(s)
-
C - Biomaterials and Tissue Engineering
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- A multi-pore spinneret system is demonstrated for the first time to achieve the goal of up-scaled production of aligned fibers. A mechanism of converting random fibers to aligned fibers with controlled patterning at low rotation-speeds is demonstrated. Pore-number of the new spinneret technology permits greater solution out-flow and therefore greater fiber production simultaneously. The production-rate of our spinneret is 120 g/hr using a low rotational speed of 70 rpm at 15 kV, which is suitable at the industrial scale. The work demonstrates a novel and significant low-cost approach for large-scale production of diverse drug-fibers and is now core to patent-CN201710579175.6.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -