Altered Mechanical Environment of Bone Cells in an Animal Model of Short- and Long-Term Osteoporosis
- Submitting institution
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The University of Sheffield
- Unit of assessment
- 12 - Engineering
- Output identifier
- 7437
- Type
- D - Journal article
- DOI
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10.1016/j.bpj.2015.02.031
- Title of journal
- Biophysical Journal
- Article number
- -
- First page
- 1587
- Volume
- 108
- Issue
- 7
- ISSN
- 0006-3495
- Open access status
- Out of scope for open access requirements
- Month of publication
- April
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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4
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This work is the first direct experimental evidence that bone micro-architecture amplifies mechanical loading sensed by osteocytes. By analysing live bone cell mechanics in native tissue, an explanation for why osteoporotic bones appear to initially strengthen, despite widespread bone loss, was substantiated. A novel loading device for a confocal microscope was designed and validated, while a digital image correlation technique was used to calculate cell mechanics. This research was highlighted by the Biophysical Journal in a ‘New and Notable’ commentary, with reviewers noting that it settles a long-standing debate with strain amplification now an accepted theory of bone mechano-sensing.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -