Development of a high-throughput ex-vivo burn wound model using porcine skin, and its application to evaluate new approaches to control wound infection
- Submitting institution
-
The University of Birmingham
- Unit of assessment
- 12 - Engineering
- Output identifier
- 77466838
- Type
- D - Journal article
- DOI
-
10.3389/fcimb.2018.00196
- Title of journal
- Frontiers in cellular and infection microbiology
- Article number
- 196
- First page
- -
- Volume
- 8
- Issue
- -
- ISSN
- 2235-2988
- Open access status
- Compliant
- Month of publication
- June
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
13
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- The novel ex-vivo model developed/presented here is a major improvement to previous low-throughput approaches (https://doi.org/10.1021/acsami.5b07372) as it supports high-throughput studies of clinical biofilm formation. It formed part of a major MRC DPFS grant (£1.0m) with the University of Bath, investigating biofilm formation in burn wounds and a smart bandage which can fluorescently detect early threshold infection (of wounds). This technology received interest from the media in the form of an ITV news interview (https://www.itv.com/news/meridian/update/2015-11-25/the-smart-bandage-that-detects-infections/) and local press coverage in the South East and South West. Toby Jenkins (A.T.A.Jenkins@bath.ac.uk) currently leads efforts for scale-up development with an industry partner (Hartmann Group).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -