Mathematical modelling of microtubule-tau protein transients: insights into the superior mechanical behavior of axon
- Submitting institution
-
University of Plymouth
- Unit of assessment
- 12 - Engineering
- Output identifier
- 150
- Type
- D - Journal article
- DOI
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10.1016/j.apm.2019.02.030
- Title of journal
- Applied Mathematical Modelling
- Article number
- -
- First page
- 452
- Volume
- 71
- Issue
- -
- ISSN
- 0307-904X
- Open access status
- Compliant
- Month of publication
- -
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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1
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This significance of this work is that it applies Kelvin-Voigt viscoelastic behaviour to elucidate the biomechanical features of microtubules and tau protein in axons when subjected to transient loading. The model characterises the relative sliding and stress transfer between microtubules and tau protein while the axon is stretched transiently. It illustrates how vulnerable axons protect themselves from damage and how they can simultaneously achieve an outstanding mechanical balance between high specific stiffness and toughness. The work reveals how viscoelastic models can be applied to explain the biomechanical features of biological materials.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -