A gradient of matrix-bound FGF-2 and perlecan is available to lens epithelial cells.
- Submitting institution
-
University of Durham
- Unit of assessment
- 12 - Engineering
- Output identifier
- 90256
- Type
- D - Journal article
- DOI
-
10.1016/j.exer.2013.12.004
- Title of journal
- Experimental Eye Research
- Article number
- -
- First page
- 10
- Volume
- 120
- Issue
- -
- ISSN
- 00144835
- Open access status
- Out of scope for open access requirements
- Month of publication
- March
- Year of publication
- 2014
- URL
-
https://doi.org/10.1016/j.exer.2013.12.004
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- To achieve healthy ageing and to combat blindness, it is critical to understand the role played by growth factors in lens epithelial cell proliferation and differentiation. We provided the first measurements of fibroblast growth factors and its gradient in the mammalian lens, this being experimentally very challenging. Our data supported the anteroposterior gradient hypothesis and provided experimental confirmation of parameter values in our bioengineering model of the mammalian lens. The work helped to attract EPSRC IAA funding and a Rosetrees Trust Interdisciplinary award (contact: Richard Miller rmiller@rosetreestrust.co.uk), this being the first time Durham University had gained a Rosetrees Trust award.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
