Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle
- Submitting institution
-
The University of Warwick
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 5879
- Type
- D - Journal article
- DOI
-
10.1073/pnas.1320474111
- Title of journal
- Proceedings of the National Academy of Sciences of the United States of America
- Article number
- -
- First page
- 9828
- Volume
- 111
- Issue
- 27
- ISSN
- 0027-8424
- Open access status
- Out of scope for open access requirements
- Month of publication
- July
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- 5 - Biological Sciences
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
12
- Research group(s)
-
A - Applied Computing
- Citation count
- 111
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Performed by an international consortium and funded by major EU research agencies, this work showed for the first time that cell divisions and the cellular clock synchronize in a 1:1 fashion. This has significant impact for novel approaches to optimising dosing time of drugs (DOI:10.1016/j.molmed.2016.03.004) or slowing down the cell cycle using clock modulating drugs for cancer therapy (DOI:10.1142/S0219720020400065). The LineageTracker software developed here is now used by other researchers to investigate cell cycle dynamics of embryonic stem cells (DOI:10.1038/s41598-019-44537-0), inheritance of cell cycle parameters in mammalian cells (DOI:doi.org/10.1371/journal.pcbi.1007054), or how growth-factor signalling works in the face of noise (DOI:10.1073/pnas.1611428114).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -