The serine proteinase hepsin is an activator of pro-matrix metalloproteinases : molecular mechanisms and implications for extracellular matrix turnover
- Submitting institution
-
University of the West of Scotland
- Unit of assessment
- 3 - Allied Health Professions, Dentistry, Nursing and Pharmacy
- Output identifier
- 10724480
- Type
- D - Journal article
- DOI
-
10.1038/s41598-017-17028-3
- Title of journal
- Scientific Reports
- Article number
- 16693
- First page
- 1
- Volume
- 7
- Issue
- -
- ISSN
- 2045-2322
- Open access status
- Compliant
- Month of publication
- December
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
19
- Research group(s)
-
C - Institute of Biomedical & Environmental Health Research
- Citation count
- 13
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- -
- Author contribution statement
- To assess whether hepsin impacts cartilage turnover via PAR2, the role for hepsin in activating PAR2 was investigated (JCL) using an in vivo PAR2 assay JCL previously developed (J Clin Invest 2013). Using mice from in-house PAR-/- knockout colonies, synovial perfusion (via laser Doppler imaging) was measured from the knee joints of parallel groups of wild-type and PAR-/- mice, before and after topical application of hepsin. The author made a substantial contribution to the design of the study, carrying out the study; analysis and interpretation of study data and helping draft the output.
- Non-English
- No
- English abstract
- -
