How blebs and pseudopods cooperate during chemotaxis
- Submitting institution
-
The University of Warwick
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 5875
- Type
- D - Journal article
- DOI
-
10.1073/pnas.1322291111
- Title of journal
- Proceedings of the National Academy of Sciences of the United States of America
- Article number
- -
- First page
- 11703
- Volume
- 111
- Issue
- 32
- ISSN
- 0027-8424
- Open access status
- Out of scope for open access requirements
- Month of publication
- August
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- 5 - Biological Sciences
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
3
- Research group(s)
-
A - Applied Computing
- Citation count
- 46
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- We show that two mechanisms employed by cells to migrate - blebs and pseudopods - that were previously thought independent, cooperate. This significantly furthered our understanding of cell motion in mechanically restricted environments, important for immune and cancer cells. This interdisciplinary collaboration led to BBSRC funding (BB/M01150X/1), recognising the importance of our novel software for cell boundary tracking (ECMM, electrostatic contour migration method) presented in this paper. ECMM became integrated in our QuimP software for cell motility analysis (go.warwick.ac.uk/quimp), facilitating high-quality research on wound healing (DOI:10.1126/scitranslmed.aal2774), or suppression of malignant outgrowth of skin cancer (DOI:10.1084/jem.20160596), and used in >100 publications.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -