Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease
- Submitting institution
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The University of Hull
- Unit of assessment
- 12 - Engineering
- Output identifier
- 1398452
- Type
- D - Journal article
- DOI
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10.1002/cnm.2645
- Title of journal
- International journal for numerical methods in biomedical engineering
- Article number
- -
- First page
- 1085
- Volume
- 30
- Issue
- 11
- ISSN
- 2040-7939
- Open access status
- Out of scope for open access requirements
- Month of publication
- May
- Year of publication
- 2014
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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3
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Prior to this work, the complex cellular interactions in multiple myeloma (MM) and the resultant highly destructive cycle of tumour development and bone destruction were poorly understood. By incorporating multiple biochemical factors linked with MM and the influence of the bone micro-environment, for the first time, this novel mathematical model is able to produce predictions of cellular behaviour which agree well with clinical observations. It shows why MM-induced bone lesions rarely heal even after complete removal of MM cells. The model is now being used to evaluate the performance of different therapies for management of MM (https://doi.org/10.1002/cnm.2735, https://doi.org/10.3233/BME-141160).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -