Mechanistic and Cytotoxicity Studies of Group IV β-Diketonate Complexes
- Submitting institution
-
The University of Huddersfield
- Unit of assessment
- 32 - Art and Design: History, Practice and Theory
- Output identifier
- 35
- Type
- D - Journal article
- DOI
-
10.1002/cmdc.201402019
- Title of journal
- ChemMedChem
- Article number
- -
- First page
- 1136
- Volume
- 9
- Issue
- 6
- ISSN
- 1860-7179
- Open access status
- Out of scope for open access requirements
- Month of publication
- April
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- 8 - Chemistry
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
8
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Group IV metal complexes have previously shown promise as novel anticancer agents. In this article the authors discuss the mechanistic and cytotoxic nature of a series of group IV ß-diketonate coordination complexes. Clear evidence that the ligands are exchangeable on the metal centre and that the ß-diketonate ligands can act as potential drug delivery vehicles of the group IV metal ions was obtained. When evaluated for the cytotoxicity against human colon adenocarcinoma (HT-29) and human breast adenocarcinoma (MCF-7) cell lines, a general trend of decreasing potency down the group IV metals was observed. The most promising results obtained were for the hafnium complexes, with the tris diphenyl ß-diketonate hafnium complex exhibiting IC50 values of 4.90.9 mm and 3.20.3 mm against HT-29 and MCF-7, respectively, which are comparable with the activity of cisplatin against the same cell lines. This tri ß-diketonate hafnium complex is the first to show potent in vitro cytotoxic activity. The results reported show that ligand design has a significant effect on the cytotoxic potential of the complexes, and that these group IV complexes warrant further evaluation as novel metal-containing anticancer agents. This research sits within the field of technical textiles and materials science.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
