[18F]tetrafluoroborate-PET/CT enables sensitive tumor and metastasis in vivo imaging in a sodium iodide symporter-expressing tumor model
- Submitting institution
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King's College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 97620285
- Type
- D - Journal article
- DOI
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10.1038/s41598-017-01044-4
- Title of journal
- Scientific Reports
- Article number
- 946
- First page
- 1
- Volume
- 7
- Issue
- 1
- ISSN
- 2045-2322
- Open access status
- Compliant
- Month of publication
- April
- Year of publication
- 2017
- URL
-
-
- Supplementary information
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- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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9
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Cell based therapies dominate the next generation of advanced medicines. However, the fate (location, survival, replication) of administered cells in-vivo often remains unknown. Understanding this is important to assess safety and efficacy. This new solution pairs a non-immunogenic radionuclide reporter gene with a new radiotracer ([18F]tetrafluoroborate), allowing for the first time extremely sensitive PET imaging-based cancer cell-tracking. The tracer is now in use in human trials (NCT03196518; NCT02907073; NCT03456908). This led to an invited follow-up manuscript in JoVE (doi.org/10.3791/57088), and underpinned successful funding applications: UKRI Higher Education Innovation Fund (Connecting Capability Fund application, CCF08-3645); EPSRC programme grant (6.4m, EP/S032789/1 workpackage7).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -