Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue
- Submitting institution
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The University of East Anglia
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 182619557
- Type
- D - Journal article
- DOI
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10.1038/ng.3221
- Title of journal
- Nature Genetics
- Article number
- -
- First page
- 367
- Volume
- 47
- Issue
- -
- ISSN
- 1061-4036
- Open access status
- Out of scope for open access requirements
- Month of publication
- April
- Year of publication
- 2015
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
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70
- Research group(s)
-
-
- Citation count
- 241
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- For the first time, whole genome sequences of multiple samples from the prostates of men with prostate cancer were analysed - both from tumours and normal tissue. Novel algorithms were developed to decrypt how the cancer evolves. The discovery that there are pre-malignant genomic changes in the normal tissue led to a wealth of further research (over 200 citations). It has led to funding for a PhD studentship (Prostate Cancer UK TLD-S15-003; £84,000) and contributed to a project grant (CRUK C5047/A22530; £1.6M). These findings have led to discussion of whether focal therapy treatment is optimal (e.g. Biology of Genomes 2015).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -