A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion
- Submitting institution
-
Heriot-Watt University
(joint submission with University of Edinburgh)
- Unit of assessment
- 12 - Engineering
- Output identifier
- 10724523
- Type
- D - Journal article
- DOI
-
10.1038/ncomms6774
- Title of journal
- Nature Communications
- Article number
- 5774
- First page
- -
- Volume
- 5
- Issue
- -
- ISSN
- 2041-1723
- Open access status
- Out of scope for open access requirements
- Month of publication
- -
- Year of publication
- 2014
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
13
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This research applies advanced single-particle-tracking methods to the study of synaptic biology in situ, by tracking large cohorts of single molecules inside active synapses. Information is obtained on the dynamics and interactions of presynaptic SNAREs, to aid the understanding of how central synapses, and membrane trafficking processes function. Subsequent development and application of this method to Ultrasound have led to the award of a patent (GB1716606.7, 2017) to aid medical imaging and diagnosis, and which was widely reported in the press (e.g. https://www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-49870017).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
